A metatarsal stress fracture occurs when the foot is overloaded. For instance, a rapid increase in hills or speed training can lead to a stress fracture. Pain caused by a metatarsal stress fracture is often localized on the top of the foot (ie. in line with the third or fourth toe), and can be very debilitating.

Plantar fasciopathy, commonly known as fasciitis, is an irritation of the fascia (connective tissue) under the foot. The plantar fascia runs between the calcaneus (heel bone) and toes, and helps support the foot’s arch. Pain develops gradually and symptoms may include foot stiffness in the morning. Pain may also increase with forefoot running.

Interdigital perineural fibroma, commonly called Morton's neuroma, refers to nerve inflammation and irritation due to nerve compression between the toes, most commonly the third and fourth toes. This condition is characterized by acute and occasionally burning pain in the forefoot, sometimes associated with numbness or tingling.